Taiwan Birth Panel Study (TBPS)

- Publications

I. Overview
  • 1. Hsieh CJ, Hsieh WS, Su YN, Liao HF, Jeng SF, Tsao FM, Hwang YH, Wu KY, Chen CY, Guo YL, Chen PC. The Taiwan Birth Panel Study: a prospective cohort study for environmentally-related child health. BMC Research Notes 2011 Aug; 4: 291. https://doi.org/10.1186/1756-0500-4-291
II. Environmental Tobacco Smoke
  • 2. Huang KH, Chou AK, Jeng SF, Ng S, Hsieh CJ, Chen MH, Chen PC, Hsieh WS. The impacts of cord blood cotinine and glutathione-S-transferase gene polymorphisms on birth outcome. Pediatrics and Neonatology 2017 Aug; 58(4): 362-369. https://doi.org/10.1016/j.pedneo.2016.08.006
  • 3. Hsieh CJ, Liao HF, Wu KY, Hsieh WS, Su YN, Jeng SF, Yu SN, Chen PC. CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age. Neurotoxicology 2008 Sep; 29(5): 839-845. https://doi.org/10.1016/j.neuro.2008.05.006
  • 4. Hsieh CJ, Jeng SF, Su YN, Liao HF, Hsieh WS, Wu KY, Chen PC. CYP1A1 modifies the effect of maternal exposure to environmental tobacco smoke on child behavior. Nicotine and Tobacco Research 2010 Nov; 12(11): 1108-1117. https://doi.org/10.1093/ntr/ntq157
  • 5. Hsieh CJ, Jeng SF, Wu KY, Su YN, Liao HF, Hsieh WS, Chen PC. GSTM1 modifies the effect of maternal exposure to environmental tobacco smoke on neonatal primitive reflexes. Nicotine and Tobacco Research 2011 Nov; 13(11): 1114-1122. https://doi.org/10.1093/ntr/NTR124
  • 6. Wang IJ, Hsieh WS, Wu KY, Guo LY, Hwang YH, Jee SH, Chen PC. Effect of gestational smoke exposure on atopic dermatitis in the offspring. Pediatric Allergy and Immunology 2008 Nov; 19(7): 580-586. https://doi.org/10.1111/j.1399-3038.2008.00759.x
  • 7. Wang IJ, Guo YL, Lin TJ, Chen PC, Wu YN. GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. Annals of Allergy, Asthma and Immunology 2010 Aug; 105(2): 124-129. https://doi.org/10.1016/j.anai.2010.04.017
  • 8. Wang IJ, Chen SL, Lu TP, Chuang EY, Chen PC. Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis. Clinical and Experimental Allergy 2013 May; 43(5): 535-543. https://doi.org/10.1111/cea.12108
III. Heavy Metals
  • 9. Liu JH, Wu HC, Chen PC, Guo YL, Hwang YH. Concentration distributions of elements in umbilical cord blood in Taiwan. Taiwan Journal of Public Health 2009 Oct; 28(5): 420-434. https://doi.org/10.6288/TJPH2009-28-05-07
  • 10. Lin YY, Guo YL, Chen PC, Liu JH, Wu HC, Hwang YH. Associations between petrol-station density and manganese and lead in the cord blood of newborns living in Taiwan. Environmental Research 2011 Feb; 111(2): 260-265. https://doi.org/10.1016/j.envres.2011.01.001
  • 11. Lin YY, Hwang YH, Chen PC, Chen BY, Wen HR, Liu JH, Guo YL. Contribution of gestational exposure to ambient traffic air pollutants to fetal cord blood manganese. Environmental Research 2012 Jan; 112(1): 1-7. https://doi.org/10.1016/j.envres.2011.11.006
  • 12. Hwang YH, Wu HC, Shyu MK, Lee CN, Lin SY, Chen PC, Chuang HY, Lin PW, Wu TH. Temporal transition trends of cord blood lead levels in various human development index countries and in the Taipei metropolitan area. Environmental Pollution 2023 Sep; 332: 121900. https://doi.org/10.1016/j.envpol.2023.121900
  • 13. Lin CM, Doyle P, Wang D, Hwang YH, Chen PC. The role of essential metals in the placental transfer of lead from mother to child. Reproductive Toxicology 2010 Jul; 29(4): 443-446. https://doi.org/10.1016/j.reprotox.2010.03.004
  • 14. Lin CM, Doyle P, Wang D, Hwang YH, Chen PC. Does prenatal cadmium exposure effect fetal and child growth? Occupational and Environmental Medicine 2011 Sep; 68(9): 641-646. https://doi.org/10.1136/oem.2010.059758
  • 15. Su FC, Liao HF, Hwang YH, Hsieh WS, Wu HC, Jeng SF, Su YN, Chen PC. In utero exposure to manganese and psychomotor development at the age of six months. Journal of Occupational Safety and Health 2007 Sep; 15(3): 204-217. https://doi.org/10.7005/JOSH.200709.0204
  • 16. Lin CC, Chen YC, Su FC, Lin CM, Liao HF, Hwang YH, Hsieh WS, Jeng SF, Su YN, Chen PC. In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. Environmental Research 2013 May; 123: 52-57. https://doi.org/10.1016/j.envres.2013.03.003
  • 17. Ng S, Lin CC, Hwang YH, Hsieh WS, Liao HF, Chen PC. Mercury, APOE, and children’s neurodevelopment. Neurotoxicology 2013 Jul; 37: 85-92. https://doi.org/10.1016/j.neuro.2013.03.012
  • 18. Ng S, Lin CC, Jeng SF, Hwang YH, Hsieh WS, Chen PC. Mercury, APOE, and child behavior. Chemosphere 2015 Feb; 120: 123-130. https://doi.org/10.1016/j.chemosphere.2014.06.003
  • 19. Kim BM, Chen MH, Chen PC, Park H, Ha M, Kim Y, Hong YC, Kim YJ, Ha EH. Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts. Science of the Total Environment 2017 Dec; 605-606: 1003-1010. https://doi.org/10.1016/j.scitotenv.2017.06.151
IV. Perfluoroalkyl Substances and Other Chemical Exposures
  • 20. Lien GW, Wen TW, Hsieh WS, Wu KY, Chen CY, Chen PC. Analysis of perfluorinated chemicals in umbilical cord blood by ultra-high performance liquid chromatography/tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011 Mar; 879(9-10): 641-646. https://doi.org/10.1016/j.jchromb.2011.01.037
  • 21. Lien GW, Huang CC, Wu KY, Chen MH, Lin CY, Chen CY, Hsieh WS, Chen PC. Neonatal-maternal factors and perfluoroalkyl substances in cord blood. Chemosphere 2013 Aug; 92(7): 843-850. https://doi.org/10.1016/j.chemosphere.2013.04.038
  • 22. Liu CY, Chen PC, Lien PC, Liao YP. Prenatal perfluorooctyl sulfonate exposure and alu DNA hypomethylation in cord blood. International Journal of Environmental Research and Public Health 2018 May; 15(6): 1066. https://doi.org/10.3390/ijerph15061066
  • 23. Chen MH, Ha EH, Wen TW, Su YN, Lien GW, Chen CY, Chen PC, Hsieh WS. Perfluorinated compounds in umbilical cord blood and adverse birth outcomes. PLoS ONE 2012 Aug; 7(8): e42474. https://doi.org/10.1371/journal.pone.0042474
  • 24. Ku MS, Pan WC, Huang YT, Hsieh WS, Hsu YH, Chen PC, Liu CY. Associations between prenatal exposure to perfluoroalkyl substances, hypomethylation of MEST imprinted gene and birth outcomes. Environmental Pollution 2022 Jul; 304: 119183. https://doi.org/10.1016/j.envpol.2022.119183
  • 25. Verner MA, Loccisano AE, Morken NH, Yoon M, Wu H, McDougall R, Maisonet M, Marcus M, Kishi R, Miyashita C, Chen MH, Hsieh WS, Andersen ME, Clewell HJ, Longnecker MP. Associations of perfluoroalkyl substances (PFAS) with lower birth weight: an evaluation of potential confounding by glomerular filtration rate using a physiologically based pharmacokinetic model (PBPK). Environmental Health Perspectives 2015 Dec; 123(12): 1317-1324. https://doi.org/10.1289/ehp.1408837​
  • 26. Chen MH, Ng S, Hsieh CJ, Lin CC, Hsieh WS, Chen PC. The impact of prenatal perfluoroalkyl substances exposure on neonatal and child growth. Science of the Total Environment 2017 Dec; 607-608: 669-675. https://doi.org/10.1016/j.scitotenv.2017.06.273
  • 27. Tsai MS, Lin CC, Chen MH, Hsieh WS, Chen PC. Perfluoroalkyl substances and thyroid hormones in cord blood. Environmental Pollution 2017 Mar; 222: 543-548. https://doi.org/10.1016/j.envpol.2016.11.027
  • 28. Chen MH, Ha EH, Liao HF, Jeng SF, Su YN, Wen TW, Lien GW, Chen CY, Hsieh WS, Chen PC. Perfluorinated compound levels in cord blood and neurodevelopment at 2 years of age. Epidemiology 2013 Nov; 24(6): 800-808. https://doi.org/10.1097/EDE.0b013e3182a6dd46
  • 29. Lien GW, Huang CC, Shiu JS, Chen MH, Hsieh WS, Guo YL, Chen PC. Perfluoroalkyl substances in cord blood and attention deficit/hyperactivity disorder symptoms in seven-year-old children. Chemosphere 2016 Aug; 156: 118-127. https://doi.org/10.1016/j.chemosphere.2016.04.102
  • 30. Wang IJ, Hsieh WS, Chen CY, Fletcher T, Lien GW, Chiang HL, Chiang CF, Wu TN, Chen PC. The effect of prenatal perfluorinated chemicals exposures on pediatric atopy. Environmental Research 2011 Aug; 111(6): 785-791. https://doi.org/10.1016/j.envres.2011.04.006
  • 31. Kung YP, Lin CC, Chen MH, Tsai MS, Hsieh WS, Chen PC. Intrauterine exposure to per- and polyfluoroalkyl substances may harm children's lung function development. Environmental Research 2021 Jan; 192: 110178. https://doi.org/10.1016/j.envres.2020.110178
  • 32. Lee SH, Tseng WC, Du ZY, Lin WY, Chen MH, Lin CC, Lien GW, Liang HJ, Weng HJ, Guo YL, Chen PC, Lin CY. Lipid responses to environmental perfluoroalkyl substance exposure in a Taiwanese child cohort. Environmental Pollution 2021; Aug; 283: 117007. https://doi.org/10.1016/j.envpol.2021.117007
  • 33. Wen HJ, Wang SL, Chen PC, Guo YL. Prenatal perfluorooctanoic acid exposure and glutathione s-transferase T1/M1 genotypes and their association with atopic dermatitis at 2 years of age. PLoS ONE 2019 Jan; 14(1): e0210708. https://doi.org/10.1371/journal.pone.0210708
  • 34. Wen HJ, Wang SL, Chuang YC, Chen PC, Guo YL. Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children. Chemosphere 2019 Sep; 231: 25-31. https://doi.org/10.1016/j.chemosphere.2019.05.100
  • 35. Chang YJ, Chen WL, Bai FY, Chen PC, Wang GS, Chen CY. Determination of perfluorinated chemicals in food and drinking water using high-flow solid-phase extraction and ultra-high performance liquid chromatography/tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2012 Jan; 402(3): 1315-1325. https://doi.org/10.1007/s00216-011-5519-9
  • 36. Wang IJ, Lin CC, Lin YJ, Hsieh WS, Chen PC. Early life phthalate exposure and atopic disorders in children: a prospective birth cohort study. Environment International 2014 Jan; 62: 48-54. https://doi.org/10.1016/j.envint.2013.09.002
  • 37. Lin LY, Tsai MS, Chen MH, Ng S, Hsieh CJ, Lin CC, Lu FL, Hsieh WS, Chen PC. Childhood exposure to phthalates and pulmonary function. Science of the Total Environment 2018 Feb; 615: 1282-1289.  https://doi.org/10.1016/j.scitotenv.2017.08.318
  • 38. Weng TI, Chen MH, Lien GW, Chen PS, Lin JCC, Fang CC, Chen PC. Effects of gender on the association of urinary phthalate metabolites with thyroid hormones in children: a prospective cohort study in Taiwan. International Journal of Environmental Research and Public Health 2017 Feb; 14(2): 123. https://doi.org/10.3390/ijerph14020123
  • 39. Lee SH, Du ZY, Tseng WC, Lin WY, Chen MH, Lin CC, Liang HJ, Wen HJ, Guo YL, Chen PC, Lin CY. Identification of serum metabolic signatures of environmental-leveled phthalate in the Taiwanese child population using NMR-based metabolomics. Environmental Pollution 2023 Jan; 316(Pt 1): 120454. https://doi.org/10.1016/j.envpol.2022.120454
  • 40. Lin CC, Chien CJ, Tsai MS, Chen MH, Hsieh WS, Chen PC. Prenatal phenolic compounds exposure and neurobehavioral development at 2 and 7 years of age. Science of the Total Environment 2017 Dec; 605-606: 801-810. https://doi.org/10.1016/j.scitotenv.2017.06.160
  • ​41. Tung CJ, Lin CC, Chen MH, Chen CY, Hsieh WS, Chen PC. Association between parabens exposure and neurodevelopment in children. Environment International 2024 Jun; 188: 108671.  https://doi.org/10.1016/j.envint.2024.108671 (TBPS2)
  • 42. Liao HT, Hsieh CJ, Chiang SY, Lin MH, Chen PC, Wu KY. Simultaneous analysis of chlorpyrifos and cypermethrin in cord blood plasma by online solid-phase extraction coupled with liquid chromatography-heated electrospray ionization tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011 Jul; 879(21): 1961-1966. https://doi.org/10.1016/j.jchromb.2011.05.028
  • 43. Chiu KC, Sisca F, Ying JH, Tsai WJ, Hsieh WH, Chen PC, Liu CY. Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child development. Environmental Pollution 2021 Apr; 274: 116511. https://doi.org/10.1016/j.envpol.2021.116511
V. Psychosocial Factors and Neurobehavioral Development
  • 44. Chuang CH, Liao HF, Hsieh WS, Jeng SF, Su YN, Chen PC. Maternal psychosocial factors around delivery on development of 2-year-old children: a prospective cohort study. Journal of Paediatrics and Child Health 2011 Jan-Feb; 47(1-2): 34-39. https://doi.org/10.1111/j.1440-1754.2010.01887.x 
  • 45. Chuang CH, Jeng SF, Hsieh WS, Liao HF, Su YN, Chen PC. Maternal psychosocial factors around delivery, and the behavior of 2-year-old children. Pediatrics International 2011 Oct; 53(5): 656-661. https://doi.org/10.1111/j.1442-200X.2010.03315
  • 46. Chen HY, Hou TW, Chuang CH, TBPS Research Group. Applying data mining to explore the risk factors of parenting stress. Expert Systems with Applications 2010 Jan; 37(1): 598-601. https://doi.org/10.1016/j.eswa.2009.05.028
  • 47. Wu PH, Lin CC, Liao HF, Tsao FM, Hsieh WS, Chen PC. Maternal mobile phone use and children’s neurocognitive development. Taiwan Journal of Public Health 2012 Oct; 31(5): 436-445. https://doi.org/10.6288/TJPH2012-31-05-05
  • 48. Kuo YL, Liao HF, Chen PC, Hsieh WS, Hwang AW. The influence of wakeful prone positioning on motor development during the early life. Journal of Developmental and Behavioral Pediatrics 2008 Oct; 29(5): 367-376. https://doi.org/10.1097/DBP.0b013e3181856d54
  • 49. Hsieh YH, Hwang AW, Liao HF, Chen PC, Hsieh WS, Chu PY. Psychometric properties of a Chinese version of the home environment measure for motor development. Disability and Rehabilitation 2011 Dec; 33(25-26): 2454-2463. https://doi.org/10.3109/09638288.2011.574775
  • 50. Wang PJ, Hwang AW, Liao HF, Chen PC, Hsieh WS. The stability of mastery motivation and its relationship with home environment in infants and toddlers. Infant Behavior and Development 2011 Jun; 34(3): 434-442. https://doi.org/10.1016/j.infbeh.2011.04.005
  • 51. Hwang AW, Liao HF, Chen PC, Hsieh WS, Simeonsson RJ, Weng LJ, Su YN. Applying the ICF-CY framework to examine biological and environmental factors in early childhood development. Journal of the Formosan Medical Association 2014 May; 113(5): 303-312. https://doi.org/10.1016/j.jfma.2011.10.004
  • 52. Wu YT, Chen WJ, Hsieh WS, Chen PC, Liao HF, Su YN, Jeng SF. Maternal-reported behavioral and emotional problems in Taiwanese preschool children. Research in Developmental Disabilities 2012; May/Jun; 33(3): 866-873. https://doi.org/10.1016/j.ridd.2011.11.018
VI. Allergic and Infectious Diseases
  • 53. Wang IJ, Hsieh WS, Guo YL, Jee SH, Hsieh CJ, Hwang YH, Chen PC. Neuro-mediators as predictors of paediatric atopic dermatitis. Clinical and Experimental Allergy 2008 Aug; 38(8): 1302-1308. https://doi.org/10.1111/j.1365-2222.2008.03026.x
  • 54. Wang IJ, Lin TJ, Kuo CF, Lin SL, Lee YL, Chen PC. Filaggrin polymorphism P478S, IgE level, and atopic phenotypes. British Journal of Dermatology 2011 Apr; 164(4): 791-796. https://doi.org/10.1111/j.1365-2133.2011.10212.x
  • 55. Su KW, Chen PC, Wang IJ. Cord blood soluble Fas ligand and pediatric atopic dermatitis. Allergy and Asthma Proceedings 2011 Sep/Oct; 32(5): 366-371. https://doi.org/10.2500/aap.2011.32.3468
  • 56. Hu IJ, Chen PC, Su FC, Hsieh CJ, Jeng SF, Liao HF, Su YN, Lin SJ, Hsieh WS. Perinatal toxoplasmosis, northern Taiwan. Emerging Infectious Diseases 2006 Sep; 12(9): 1460-1461. https://doi.org/10.3201/eid1209.060033
  • 57. Chen MH, Chen PC, Jeng SF, Hsieh CJ, Su FC, Liao HF, Su YN, Lin SJ, Hsieh WS. High perinatal seroprevalence of cytomegalovirus in northern Taiwan. Journal of Paediatrics and Child Health 2008 Apr; 44(4): 166-169. https://doi.org/10.1111/j.1440-1754.2007.01215.x
VII. Others
  • 58. Liao CW, Wei CF, Chen MH, Hsieh WS, Lin CC, Chen PC. Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood. Frontiers in Public Health 2022 Sep; 10: 1006332. https://doi.org/10.3389/fpubh.2022.1006332 (TBPS2)
  • 59. Lai CY, Wu YT, Yu SL, Yu YH, Lee SY, Liu CM, Hsieh WS, Hwu HG, Chen PC, Jeng SF, Chen WJ. Modulated expression of human peripheral blood microRNAs from infancy to adulthood and its role in aging. Aging Cell 2014 Aug; 13(4): 679-689. https://doi.org/10.1111/acel.12225
  • 60. Chen CH, Lee YL, Wu MH, Chen PJ, Wei TS, Chen PC, Tseng CI, Chen WJ. Sex moderated interactions between IL4/IL13 pathway genes and prenatal environment on cord blood IgE levels. Clinical and Experimental Allergy 2019 Aug; 49(8): 1128-1138. https://doi.org/10.1111/cea.13419