◆ Occupational and Environmental Medicine

- Reproductive Hazards in the Workplace and Environment

  • Review: Chen PC. Environmental and occupational hazards on reproduction and development. Journal of Internal Medicine ROC 1996 Mar; 7(1): 69-77.
  • Ethylene glycol ethers: Hsieh GY, Wang JD, Cheng TJ, Chen PC. Prolonged menstrual cycles in female workers exposed to ethylene glycol ethers in the semiconductor manufacturing industry. Occupational and Environmental Medicine 2005 Aug; 62(8): 510-516. https://doi.org/10.1136/oem.2004.016014
  • Ethylene glycol ethers: Chen PC, Hsieh GY, Wang JD, Cheng TJ. Prolonged time to pregnancy in female workers exposed to ethylene glycol ethers in semiconductor manufacturing. Epidemiology 2002 Mar: 13(2): 191-196. https://doi.org/10.1097/00001648-200203000-00014
  • Ethylene glycol ethers: Lin CC, Wang JD, Hsieh GY, Chang YY, Chen PC. Increased risk of deaths with congenital anomalies in the offspring of male semiconductor workers. International Journal of Occupational and Environmental Health 2008 Apr-Jun; 14(2): 112-116. https://doi.org/10.1179/oeh.2008.14.2.112
  • Ethylene glycol ethers: Lin CC, Wang JD, Hsieh GY, Chang YY, Chen PC. Health risk in the offspring of female semiconductor workers. Occupational Medicine (London) 2008 Sep; 58(6): 388-392. https://doi.org/10.1093/occmed/kqn046
  • Ethylene glycol ethers: Weng SP, Wu TCJ, Chen SU, Wu J, Lin CC, Yang YC, Chen PC. The impact of ethylene glycol monomethyl ether on ovarian function may extend to the next generation in female mice: a preliminary study. Reproductive Toxicology 2010 Jul; 29(4): 452-457. https://doi.org/10.1016/j.reprotox.2010.03.009
  • Organic solvents: Lin CC, Huang CN, Hwang YH, Wang JD, Weng SP, Shie RH, Chen PC. Shortened menstrual cycles in LCD manufacturing workers. Occupational Medicine (London) 2013 Jan; 63(1): 45-52. https://doi.org/10.1093/occmed/kqs172
  • Organic solvents: Lin CC, Huang CN, Wang JD, Hwang YH, Shie RH, Chang YY, Weng SP, Chen PC. Exposure to multiple low-level chemicals in relation to reproductive hormones in premenopausal women involved in liquid crystal display manufacture. International Journal of Environmental Research and Public Health 2013 Apr; 10(4): 1406-1417. https://doi.org/10.3390/ijerph10041406
  • Organic solvents: Sung TI, Chen PC, Lee LJH, Lin YP, Hsieh GY, Wang JD. Increased standardized incidence ratio of breast cancer in female electronic workers. BMC Public Health 2007 Jun; 7: 102. https://doi.org/10.1186/1471-2458-7-102
  • Organic solvents: Sung TI, Wang JD, Chen PC. Increased risks of infant mortality and deaths due to congenital malformation in the offspring of male electronics workers. Birth Defects Research Part A: Clinical and Molecular Teratology 2009 Feb; 85(2): 119-124. https://doi.org/10.1002/bdra.20496
  • Organic solvents: Sung TI, Wang JD, Chen PC. Increased risk of cancer in the offspring of female electronics workers. Reproductive Toxicology 2008 Jan; 25(1): 115-119. https://doi.org/10.1016/j.reprotox.2007.08.004
  • Lead: Shiau CY, Wang JD, Chen PC. Decreased fecundity among male lead workers. Occupational and Environmental Medicine 2004 Nov; 61(11): 915-923. https://doi.org/10.1136/oem.2004.014944
  • Lead: Chen PC, Pan IJ, Wang JD. Parental exposure to lead and small for gestational age births. American Journal of Industrial Medicine 2006 Jun; 49(6): 417-422. https://doi.org/10.1002/ajim.20313
  • Ionizing radiation: Lin CM, Chang WP, Doyle P, Wang JD, Lee LT, Lee CL, Chen PC. Prolonged time to pregnancy in residents exposed to ionising radiation in cobalt-60-contaminated buildings. Occupational and Environmental Medicine 2010 Mar; 67(3): 187-195. https://doi.org/10.1136/oem.2008.045260
  • Polychlorinated biphenyls: Yang CY, Wang YJ, Chen PC, Tsai SJ, Guo YL. Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental Health Perspectives 2008 May; 116(5): 599-604. https://doi.org/10.1289/ehp.10715

- Children's Environmental Health

  • Review: Tsai MS, Chen MH, Lin CC, Ng S, Hsieh CJ, Liu CY, Hsieh WS, Chen PC. Children’s environmental health based on birth cohort studies of Asia. Science of the Total Environment 2017 Dec; 609: 396-409. https://doi.org/10.1016/j.scitotenv.2017.07.081
  • Review: Tsai MS, Chen MH, Lin CC, Liu CY, Chen PC. Children’s environmental health based on birth cohort studies of Asia (2) - air pollution, pesticides, and heavy metals. Environmental Research 2019 Dec; 179A: 108754.  https://doi.org/10.1016/j.envres.2019.108754
  • Review: Chen MH, Ng S, Tsai MS, Lin CC, Chen PC. 12. Birth Cohort Consortium of Asia (BiCCA): Current children’s environmental health issues in Asia and future perspectives. In: Sata F, Fukuoka H, Hanson M, eds. Pre-emptive Medicine: Public Health Aspects of Developmental Origins of Health and Disease (ISBN: 978-981-13-2193-1, 978-981-13-2194-8 (eBook)). Current Topics in Environmental Health and Preventive Medicine. Singapore: Springer Nature Singapore Pte Ltd, 2019: 189-197.
  • Review: Lin CC, Tsai MS, Chen MH, Chen PC. Chapter 11. Mercury, lead, manganese, and hazardous metals. In: Kishi R, Grandjean P, eds. Health Impacts of Developmental Exposure to Environmental Chemicals (ISBN: 978-981-15-0519-5, 978-981-15-0520-1 (eBook)). Current Topics in Environmental Health and Preventive Medicine. Singapore: Springer Nature Singapore Pte Ltd, 2020: 247-277.
  • Overview: Kishi R, Zhang JJ, Ha EH, Chen PC, Tian Y, Xia Y, Tsuchiya KJ, Nakai K, Kim S, Hong SJ, Hong YC, Lee JR, Jan Mohamed HJB, Parajuli RP, Adair LS, Chong YS, Guo YL, Wang SL, Nishijo M, Kido T, Tai PT, Nandasena S. Birth Cohort Consortium of Asia: Current and Future Perspectives. Epidemiology 2017 Oct; 28(Suppl 1): S19-S34.  https://doi.org/10.1097/EDE.0000000000000698
  • Overview: Hsieh CJ, Hsieh WS, Su YN, Liao HF, Jeng SF, Tsao FM, Hwang YH, Wu KY, Chen CY, Guo YL, Chen PC. The Taiwan Birth Panel Study: a prospective cohort study for environmentally-related child health. BMC Research Notes 2011 Aug; 4: 291. https://doi.org/10.1186/1756-0500-4-291
  • Melamine: Wang IJ, Chen PC, Hwang KC. Melamine and nephrolithiasis in children in Taiwan. New England Journal of Medicine 2009 Mar; 360(11): 1157-1158. https://doi.org/10.1056/nejmc0810070
  • Melamine: Wang IJ, Wu YN, Wu WC, Leonardi G, Sung YJ, Lin TJ, Wang CL, Kuo CF, Wu KY, Cheng WC, Chan CC, Chen PC, Lin SL. The association of clinical findings and exposure profiles with melamine associated nephrolithiasis. Archives of Disease in Childhood 2009 Nov; 94(11): 883-887. https://doi.org/10.1136/adc.2009.163477
  • Melamine: Wang IJ, Huang YC, Chen PC, Wu TN. Is screening cost-effective for melamine-associated nephrolithiasis? Journal of Tropical Pediatrics 2011 Apr; 57(2): 141-143. https://doi.org/10.1093/tropej/fmq059
  • Melamine: Wang IJ, Chen CC, Chan CC, Chen PC, Wu KY. A hierarchical Bayesian approach for risk assessment of melamine in infant formula based on cases of related nephrolithiasis in children. Food Additives and Contaminants - Part A Chemistry, Analysis, Control, Exposure and Risk Assessment 2011 Apr; 28(4): 384-395. https://doi.org/10.1080/19440049.2010.548083
  • Smoking: Su FC, Lee MC, Hsieh WS, Chang PJ, Guo YL, Hurng BS, Lin SJ, Chen PC. The effect of prenatal and postnatal environmental tobacco smoke exposure on infant health. Taiwan Journal of Public Health 2007 Dec; 26(6): 472-481. https://doi.org/10.6288/TJPH2007-26-06-04
  • Smoking: Ko TJ, Tsai LY, Chu LC, Yeh SJ, Leung C, Chen CY, Chou HC, Tsao PN, Chen PC, Hsieh WS. Parental smoking during pregnancy and its association with low birth weight, small for gestational age, and preterm birth offspring: A birth cohort study. Pediatrics and Neonatology 2014 Feb; 55(1): 20-27. https://doi.org/10.1016/j.pedneo.2013.05.005
  • Smoking: Huang KH, Chou AK, Jeng SF, Ng S, Hsieh CJ, Chen MH, Chen PC, Hsieh WS. The impacts of cord blood cotinine and glutathione-S-transferase gene polymorphisms on birth outcome. Pediatrics and Neonatology 2017 Aug; 58(4): 362-369. https://doi.org/10.1016/j.pedneo.2016.08.006
  • Smoking: Hsieh CJ, Liao HF, Wu KY, Hsieh WS, Su YN, Jeng SF, Yu SN, Chen PC. CYP1A1 Ile462Val and GSTT1 modify the effect of cord blood cotinine on neurodevelopment at 2 years of age. Neurotoxicology 2008 Sep; 29(5): 839-845. https://doi.org/10.1016/j.neuro.2008.05.006
  • Smoking: Hsieh CJ, Jeng SF, Su YN, Liao HF, Hsieh WS, Wu KY, Chen PC. CYP1A1 modifies the effect of maternal exposure to environmental tobacco smoke on child behavior. Nicotine and Tobacco Research 2010 Nov; 12(11): 1108-1117. https://doi.org/10.1093/ntr/ntq157
  • Smoking: Hsieh CJ, Jeng SF, Wu KY, Su YN, Liao HF, Hsieh WS, Chen PC. GSTM1 modifies the effect of maternal exposure to environmental tobacco smoke on neonatal primitive reflexes. Nicotine and Tobacco Research 2011 Nov; 13(11): 1114-1122. https://doi.org/10.1093/ntr/NTR124
  • Smoking: Wei CF, Lin CC, Tsai MS, Guo YL, Lin SJ, Liao HF, Hsieh WS, Chen MH, Chen PC. Associations between infant developmental delays and secondhand smoke exposure modified by maternal prepregnancy overweight and obesity status. Nicotine and Tobacco Research 2021 Sep; 23(9): 1475-1483. https://doi.org/10.1093/ntr/ntab024
  • Smoking: Wang IJ, Hsieh WS, Wu KY, Guo LY, Hwang YH, Jee SH, Chen PC. Effect of gestational smoke exposure on atopic dermatitis in the offspring. Pediatric Allergy and Immunology 2008 Nov; 19(7): 580-586. https://doi.org/10.1111/j.1399-3038.2008.00759.x
  • Smoking: Wang IJ, Guo YL, Lin TJ, Chen PC, Wu YN. GSTM1, GSTP1, prenatal smoke exposure, and atopic dermatitis. Annals of Allergy, Asthma and Immunology 2010 Aug; 105(2): 124-129. https://doi.org/10.1016/j.anai.2010.04.017
  • Smoking: Wang IJ, Chen SL, Lu TP, Chuang EY, Chen PC. Prenatal smoke exposure, DNA methylation, and childhood atopic dermatitis. Clinical and Experimental Allergy 2013 May; 43(5): 535-543. https://doi.org/10.1111/cea.12108
  • Smoking: Chen CH, Lee Y, Wu MH, Chen PJ, Wei TS, Chen PC, Tseng CI, Chen WJ. Sex moderated interactions between IL4/IL13 pathway genes and prenatal environment on cord blood IgE levels. Clinical and Experimental Allergy 2019 Aug; 49(8): 1128-1138. https://doi.org/10.1111/cea.13419
  • Incense burning: Wei CF, Chen MH, Lin CC, Guo YL, Lin SJ, Hsieh WS, Chen PC. Household incense burning and infant gross motor development: results from the Taiwan Birth Cohort Study. Environment International 2018 Jun; 115: 110-116. https://doi.org/10.1016/j.envint.2018.03.005
  • Incense burning: Wei CF, Lin CC, Tsai MS, Guo YL, Lin SJ, Liao HF, Hsieh WS, Chen MH, Chen PC. Associations between household incense burning and delayed motor development among preterm infants modified by gestational age and maternal educational status. Indoor Air 2021 May; 31(3): 660-672. https://doi.org/10.1111/ina.12762
  • Heavy metals: Liu JH, Wu HC, Chen PC, Guo YL, Hwang YH. Concentration distributions of elements in umbilical cord blood in Taiwan. Taiwan Journal of Public Health 2009 Oct; 28(5): 420-434. https://doi.org/10.6288/TJPH2009-28-05-07
  • Heavy metals: Lin YY, Guo YL, Chen PC, Liu JH, Wu HC, Hwang YH. Associations between petrol-station density and manganese and lead in the cord blood of newborns living in Taiwan. Environmental Research 2011 Feb; 111(2): 260-265. https://doi.org/10.1016/j.envres.2011.01.001
  • Heavy metals: Lin YY, Hwang YH, Chen PC, Chen BY, Wen HR, Liu JH, Guo YL. Contribution of gestational exposure to ambient traffic air pollutants to fetal cord blood manganese. Environmental Research 2012 Jan; 112(1): 1-7. https://doi.org/10.1016/j.envres.2011.11.006
  • Heavy metals: Hwang YH, Wu HC, Shyu MK, Lee CN, Lin SY, Chen PC, Chuang HY, Lin PW, Wu TH. Temporal transition trends of cord blood lead levels in various human development index countries and in the Taipei metropolitan area. Environmental Pollution 2023 Sep; 332: 121900. https://doi.org/10.1016/j.envpol.2023.121900
  • Heavy metals: Lin CM, Doyle P, Wang D, Hwang YH, Chen PC. The role of essential metals in the placental transfer of lead from mother to child. Reproductive Toxicology 2010 Jul; 29(4): 443-446. https://doi.org/10.1016/j.reprotox.2010.03.004
  • Heavy metals: Lin CM, Doyle P, Wang D, Hwang YH, Chen PC. Does prenatal cadmium exposure effect fetal and child growth? Occupational and Environmental Medicine 2011 Sep; 68(9): 641-646. https://doi.org/10.1136/oem.2010.059758
  • Heavy metals: Chiu SY, Lin HT, Lin MH, Ho WC, Chen PC, Huang HY. The integration of recipes with a standardizable food description FACET for cadmium exposure risk assessment. International Journal of Environmental Research and Public Health 2019 Nov; 16(23): 4825. https://doi.org/10.3390/ijerph16234825
  • Heavy metals: Su FC, Liao HF, Hwang YH, Hsieh WS, Wu HC, Jeng SF, Su YN, Chen PC. In utero exposure to manganese and psychomotor development at the age of six months. Journal of Occupational Safety and Health 2007 Sep; 15(3): 204-217. https://doi.org/10.7005/JOSH.200709.0204
  • Heavy metals: Lin CC, Chen YC, Su FC, Lin CM, Liao HF, Hwang YH, Hsieh WS, Jeng SF, Su YN, Chen PC. In utero exposure to environmental lead and manganese and neurodevelopment at 2 years of age. Environmental Research 2013 May; 123: 52-57. https://doi.org/10.1016/j.envres.2013.03.003
  • Heavy metals: Ng S, Lin CC, Hwang YH, Hsieh WS, Liao HF, Chen PC. Mercury, APOE, and children’s neurodevelopment. Neurotoxicology 2013 Jul; 37: 85-92. https://doi.org/10.1016/j.neuro.2013.03.012
  • Heavy metals: Ng S, Lin CC, Jeng SF, Hwang YH, Hsieh WS, Chen PC. Mercury, APOE, and child behavior. Chemosphere 2015 Feb; 120: 123-130. https://doi.org/10.1016/j.chemosphere.2014.06.003
  • Heavy metals: Kim BM, Chen MH, Chen PC, Park H, Ha M, Kim Y, Hong YC, Kim YJ, Ha EH. Path analysis of prenatal mercury levels and birth weights in Korean and Taiwanese birth cohorts. Science of the Total Environment 2017 Dec; 605-606: 1003-1010. https://doi.org/10.1016/j.scitotenv.2017.06.151
  • Mobile phone use: Wu PH, Lin CC, Liao HF, Tsao FM, Hsieh WS, Chen PC. Maternal mobile phone use and children’s neurocognitive development. Taiwan Journal of Public Health 2012 Oct; 31(5): 436-445. https://doi.org/10.6288/TJPH2012-31-05-05
  • Maternal employment: Wang IJ, Wen HJ, Chiang TL, Lin SJ, Chen PC, Guo YL. Maternal employment and atopic dermatitis in children: A prospective cohort study. British Journal of Dermatology 2013 Apr; 168(4): 794-801. https://doi.org/10.1111/bjd.12195
  • Home environment: Wang IJ, Guo YL, Hwang KC, Hsieh WS, Chuang YL, Lin SJ, Chen PC. Genetic and environmental predictors for pediatric atopic dermatitis. Acta Paediatrica Taiwanica 2006 Sep/Oct; 47(5): 238-242. https://doi.org/10.7097/APT.200610.0238
  • Home environment: Wang IJ, Guo YL, Wen HJ, Hsieh WS, Chuang YL, Lin SJ, Chen PC. Environmental risk factors for early infantile atopic dermatitis. Pediatric Allergy and Immunology 2007 Aug; 18(5): 441-447. https://doi.org/10.1111/j.1399-3038.2007.00550.x
  • Home environment: Wen HJ, Chen PC, Chiang TL, Lin SJ, Chuang YL, Guo YL. Predicting risk for early infantile atopic dermatitis by hereditary and environmental factors. British Journal of Dermatology 2009 Nov; 161(5): 1166-1172. https://doi.org/10.1111/j.1365-2133.2009.09412.x
  • Home environment: Chen CH, Wen HJ, Chen PC, Lin SJ, Chiang TL, Hsieh IC, Guo YL. Prenatal and postnatal risk factors for infantile pneumonia in a representative birth cohort. Epidemiology and Infection 2012 Jul; 140(7): 1277-1285. https://doi.org/10.1017/S0950268811001890

- Health Effects of Environmental Contaminants

  • Per- and polyfluoroalkyl substances: Lien GW, Wen TW, Hsieh WS, Wu KY, Chen CY, Chen PC. Analysis of perfluorinated chemicals in umbilical cord blood by ultra-high performance liquid chromatography/tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011 Mar; 879(9-10): 641-646. https://doi.org/10.1016/j.jchromb.2011.01.037
  • Per- and polyfluoroalkyl substances: Lien GW, Huang CC, Wu KY, Chen MH, Lin CY, Chen CY, Hsieh WS, Chen PC. Neonatal-maternal factors and perfluoroalkyl substances in cord blood. Chemosphere 2013 Aug; 92(7): 843-850. https://doi.org/10.1016/j.chemosphere.2013.04.038
  • Per- and polyfluoroalkyl substances: Liu CY, Chen PC, Lien PC, Liao YP. Prenatal perfluorooctyl sulfonate exposure and alu DNA hypomethylation in cord blood. International Journal of Environmental Research and Public Health 2018 May; 15(6): 1066. https://doi.org/10.3390/ijerph15061066
  • Per- and polyfluoroalkyl substances: Chen MH, Ha EH, Wen TW, Su YN, Lien GW, Chen CY, Chen PC, Hsieh WS. Perfluorinated compounds in umbilical cord blood and adverse birth outcomes. PLoS ONE 2012 Aug; 7(8): e42474. https://doi.org/10.1371/journal.pone.0042474
  • Per- and polyfluoroalkyl substances: Ku MS, Pan WC, Huang YT, Hsieh WS, Hsu YH, Chen PC, Liu CY. Associations between prenatal exposure to perfluoroalkyl substances, hypomethylation of MEST imprinted gene and birth outcomes. Environmental Pollution 2022 Jul; 304: 119183. https://doi.org/10.1016/j.envpol.2022.119183
  • Per- and polyfluoroalkyl substances: Chen MH, Ng S, Hsieh CJ, Lin CC, Hsieh WS, Chen PC. The impact of prenatal perfluoroalkyl substances exposure on neonatal and child growth. Science of the Total Environment 2017 Dec; 607-608: 669-675. https://doi.org/10.1016/j.scitotenv.2017.06.273
  • Per- and polyfluoroalkyl substances: Tsai MS, Lin CC, Chen MH, Hsieh WS, Chen PC. Perfluoroalkyl substances and thyroid hormones in cord blood. Environmental Pollution 2017 Mar; 222: 543-548. https://doi.org/10.1016/j.envpol.2016.11.027
  • Per- and polyfluoroalkyl substances: Chen MH, Ha EH, Liao HF, Jeng SF, Su YN, Wen TW, Lien GW, Chen CY, Hsieh WS, Chen PC. Perfluorinated compound levels in cord blood and neurodevelopment at 2 years of age. Epidemiology 2013 Nov; 23(6): 800-808. https://doi.org/10.1097/EDE.0b013e3182a6dd46
  • Per- and polyfluoroalkyl substances: Lien GW, Huang CC, Shiu JS, Chen MH, Hsieh WS, Guo YL, Chen PC. Perfluoroalkyl substances in cord blood and attention deficit/hyperactivity disorder symptoms in seven-year-old children. Chemosphere 2016 Aug; 156: 118-127. https://doi.org/10.1016/j.chemosphere.2016.04.102
  • Per- and polyfluoroalkyl substances: Wang IJ, Hsieh WS, Chen CY, Fletcher T, Lien GW, Chiang HL, Chiang CF, Wu TN, Chen PC. The effect of prenatal perfluorinated chemicals exposures on pediatric atopy. Environmental Research 2011 Aug; 111(6): 785-791. https://doi.org/10.1016/j.envres.2011.04.006
  • Per- and polyfluoroalkyl substances: Kung YP, Lin CC, Chen MH, Tsai MS, Hsieh WS, Chen PC. Intrauterine exposure to per- and polyfluoroalkyl substances may harm children's lung function development. Environmental Research 2021 Jan; 192: 110178. https://doi.org/10.1016/j.envres.2020.110178
  • Per- and polyfluoroalkyl substances: Lee SH, Tseng WC, Du ZY, Lin WY, Chen MH, Lin CC, Lien GW, Liang HJ, Weng HJ, Guo YL, Chen PC, Lin CY. Lipid responses to environmental perfluoroalkyl substance exposure in a Taiwanese child cohort. Environmental Pollution 2021 Aug; 283: 11707. https://doi.org/10.1016/j.envpol.2021.117007
  • Per- and polyfluoroalkyl substances: Wang Y, Adgent M, Su PH, Chen HY, Chen PC, Hsiung CA, Wang SL. Prenatal exposure to perfluorocarboxylic acids (PFCAs) and fetal and postnatal growth in the Taiwan Maternal and Infant Cohort Study. Environmental Health Perspectives 2016 Nov;124(11): 1794-1800. https://doi.org/10.1289/ehp.1509998
  • Per- and polyfluoroalkyl substances: Wang Y, Rogan WJ, Chen PC, Lien GW, Chen HY, Tseng YC, Longnecker MP, Wang SL. Association between maternal serum perfluoroalkyl substances during pregnancy and maternal and cord thyroid hormones: Taiwan maternal and infant cohort study. Environmental Health Perspectives 2014 May; 122(5): 529-534. https://doi.org/10.1289/ehp.1306925
  • Per- and polyfluoroalkyl substances: Wang Y, Rogan WJ, Chen HY, Chen PC, Su PH, Chen HY, Wang SL. Prenatal exposure to perfluroalkyl substances and children's IQ: The Taiwan maternal and infant cohort study. International Journal of Hygiene and Environmental Health 2015 Oct; 218(7): 639-644. https://doi.org/10.1016/j.ijheh.2015.07.002
  • Per- and polyfluoroalkyl substances: Wen HJ, Wang SL, Chen PC, Guo YL. Prenatal perfluorooctanoic acid exposure and glutathione s-transferase T1/M1 genotypes and their association with atopic dermatitis at 2 years of age. PLoS ONE 2019 Jan; 14(1): e0210708. https://doi.org/10.1371/journal.pone.0210708
  • Per- and polyfluoroalkyl substances: Wen HJ, Wang SL, Chuang YC, Chen PC, Guo YL. Prenatal perfluorooctanoic acid exposure is associated with early onset atopic dermatitis in 5-year-old children. Chemosphere 2019 Sep; 231: 25-31.  https://doi.org/10.1016/j.chemosphere.2019.05.100
  • Per- and polyfluoroalkyl substances: Bao J, Lee YL, Chen PC, Jin YH, Dong GH. Perfluoroalkyl acids in blood serum samples from children in Taiwan. Environmental Science and Pollution Research 2014 Jun; 21(12): 7650-7655. https://doi.org/10.1007/s11356-014-2594-4
  • Per- and polyfluoroalkyl substances: Dong GH, Tung KY, Tsai CH, Liu MM, Wang D, Liu W, Jin YH, Hsieh WS, Lee YL, Chen PC. Serum polyfluoroalkyl concentrations, asthma outcomes, and immunological markers in a case-control study of Taiwanese children. Environmental Health Perspectives 2013 Apr; 121(4): 507-513. https://doi.org/10.1289/ehp.1205351
  • Per- and polyfluoroalkyl substances: Qin XD, Qian Z, Vaughn MG, Huang J, Ward P, Zeng XW, Zhou Y, Zhu Y, Yuan P, Li M, Bai Z, Paul G, Hao YT, Chen W, Chen PC, Dong GH, Lee YL. Positive associations of serum perfluoroalkyl substances with uric acid and hyperuricemia in children from Taiwan. Environmental Pollution 2016 May; 212: 519-524. https://doi.org/10.1016/j.envpol.2016.02.050
  • Per- and polyfluoroalkyl substances: Zhou Y, Hu LW, Qian ZM, Chang JJ, King C, Paul G, Lin S, Chen PC, Lee YL, Dong GH. Association of perfluoroalkyl substances exposure with reproductive hormone levels in adolescents: by sex status. Environment International 2016 Sep; 94: 189-195. https://doi.org/10.1016/j.envint.2016.05.018
  • Per- and polyfluoroalkyl substances: Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SHJ, Chien KL, Sung FC, Chen PC, Su TC. Associations between levels of serum perfluorinated chemicals and adiponectin in a young hypertension cohort in Taiwan. Environmental Science and Technology 2011 Dec; 45(24): 10691-10698. https://doi.org/10.1021/es201964x
  • Per- and polyfluoroalkyl substances: Lin CY, Wen LL, Lin LY, Wen TW, Lien GW, Chen CY, Hsu SHJ, Chien KL, Liao CC, Sung FC, Chen PC, Su TC. The associations between serum perfluorinated chemicals and thyroid function in adolescents and young adults. Journal of Hazardous Materials 2013 Jan; 244-245: 637-644. https://doi.org/10.1016/j.jhazmat.2012.10.049
  • Per- and polyfluoroalkyl substances: Lin CY, Lin LY, Wen TW, Lien GW, Wen LL, Chien KL, Hsu SHJ, Sung FC, Chen PC, Su TC. Association between levels of serum perfluorooctane sulfate and carotid artery intima-media thickness in adolescents and young adults. International Journal of Cardiology 2013 Oct; 168(4): 3309-3316. https://doi.org/10.1016/j.ijcard.2013.04.042
  • Per- and polyfluoroalkyl substances: Lin CY, Chen PC, Lo SC, Torng PL, Sung FC, Su TC. The association of carotid intima-media thickness with serum level of perfluorinated chemicals and endothelium-platelet microparticles in adolescents and young adults. Environment International 2016 Sep; 94: 292-299. https://doi.org/10.1016/j.envint.2016.06.004
  • Per- and polyfluoroalkyl substances: Tsai MS, Lin CY, Lin CC, Chen MH, Hsu SHJ, Chien KL, Sung FC, Chen PC, Su TC. Association between perfluoroalkyl substances and reproductive hormones in adolescents and young adults. International Journal of Hygiene and Environmental Health 2015 Jul; 218(5): 437-443. https://doi.org/10.1016/j.ijheh.2015.03.008
  • Per- and polyfluoroalkyl substances: Su TC, Kuo CC, Hwang JJ, Lien GW, Chen MF, Chen PC. Serum perfluorinated chemicals, glucose homeostasis and the risk of diabetes in working-aged Taiwanese adults. Environment International 2016 Mar; 88: 15-22. https://doi.org/10.1016/j.envint.2015.11.016
  • Per- and polyfluoroalkyl substances: Lin TW, Chen MK, Lin CC, Chen MH, Tsai MS, Chan DC, Hung KY, Chen PC. Association between exposure to perfluoroalkyl substances and metabolic syndrome and related outcomes among older residents living near a science park in Taiwan. International Journal of Hygiene and Environmental Health 2020 Sep; 230: 113607. https://doi.org/10.1016/j.ijheh.2020.113607
  • Per- and polyfluoroalkyl substances: Tsai MS, Chang SH, Kuo WH, Kuo CH, Li SY, Wang MY, Chang DY, Lu YS, Huang CS, Cheng AL, Lin CH, Chen PC. A case-control study of perfluoroalkyl substances and the risk of breast cancer in Taiwanese women. Environment International 2020 Sep; 142: 105850. https://doi.org/10.1016/j.envint.2020.105850
  • Per- and polyfluoroalkyl substances: Chang YJ, Chen WL, Bai FY, Chen PC, Wang GS, Chen CY. Determination of perfluorinated chemicals in food and drinking water using high-flow solid-phase extraction and ultra-high performance liquid chromatography/tandem mass spectrometry. Analytical and Bioanalytical Chemistry 2012 Jan; 402(3): 1315-1325. https://doi.org/10.1007/s00216-011-5519-9
  • Per- and polyfluoroalkyl substances: Chen WL, Bai FY, Chang YC, Chen PC, Chen CY. Concentrations of perfluoroalkyl substances in foods and the dietary exposure among Taiwan general population and pregnant women. Journal of Food and Drug Analysis 2018 Jul; 26(3): 994-1004. https://doi.org/10.1016/j.jfda.2017.12.011
  • Per- and polyfluoroalkyl substances: Lin CY, Chen PC, Lin YC, Lin LY. Association among serum perfluoroalkyl chemicals, glucose homeostasis, and metabolic syndrome in adolescents and adults. Diabetes Care 2009 Apr; 32(4): 702-707. https://doi.org/10.2337/dc08-1816
  • Per- and polyfluoroalkyl substances: Lin CY, Lin LY, Chiang CK, Wang WJ, Su YN, Hung KY, Chen PC. Investigation of the associations between low-dose serum perfluorinated chemicals and liver enzymes in US adults. American Journal of Gastroenterology 2010 Jun; 105(6): 1354-1363. https://doi.org/10.1038/ajg.2009.707
  • Per- and polyfluoroalkyl substances: Wen LL, Lin LY, Su TC, Chen PC, Lin CY. Association between serum perfluorinated chemicals and thyroid function in US adults: The National Health and Nutrition Examination Survey 2007-2010. Journal of Clinical Endocrinology and Metabolism 2013 Sep; 98(9): E1456-E1464. https://doi.org/10.1210/jc.2013-1282 
  • Per- and polyfluoroalkyl substances: Lin LY, Wen LL, Su TC, Chen PC, Lin CY. Negative association between serum perfluorooctane sulfate concentration and bone mineral density in US premenopausal women: NHANES, 2005-2008. Journal of Clinical Endocrinology and Metabolism 2014 Jun; 99(6): 2173-2180. https://doi.org/10.1210/jc.2013-3409
  • Phthalates: Lien GW, Chen JH, Tien FW, Chen PC, Chen HW, Hwa HL, Fang CC, Weng TI, Chen PS. Dilute-and-shoot enhances sensitivity of phthalate urinary concentrations for assessing the exposure in children. Journal of Hazardous Materials 2018 Jun; 351: 124-130. https://doi.org/10.1016/j.jhazmat.2018.02.050
  • Phthalates: Wang IJ, Lin CC, Lin YJ, Hsieh WS, Chen PC. Early life phthalate exposure and atopic disorders in children: a prospective birth cohort study. Environment International 2014 Jan; 62: 48-54. https://doi.org/10.1016/j.envint.2013.09.002
  • Phthalates: Lin LY, Tsai MS, Chen MH, Ng S, Hsieh CJ, Lin CC, Lu FL, Hsieh WS, Chen PC. Childhood exposure to phthalates and pulmonary function. Science of the Total Environment 2018 Feb; 615: 1282-1289.  https://doi.org/10.1016/j.scitotenv.2017.08.318
  • Phthalates: Weng TI, Chen MH, Lien GW, Chen PS, Lin JCC, Fang CC, Chen PC. Effects of gender on the association of urinary phthalate metabolites with thyroid hormones in children: a prospective cohort study in Taiwan. International Journal of Environmental Research and Public Health 2017 Feb; 14(2): 123. https://doi.org/10.3390/ijerph14020123
  • Phthalates: Hwa HL, Peng FS, Ting TT, Chen HW, Chan HY, Yang DP, Chen PC, Kuo YN Chen PS. Monitoring phthalates in maternal and cord blood: implications for prenatal exposure and birth outcomes. Environmental Toxicology and Chemistry 2022 Mar; 41(3): 715-725. https://doi.org/10.1002/etc.5280
  • Phthalates: Lin CY, Hsieh CJ, Lo SC, Chen PC, Torng PL, Hu A, Sung FC, Su TC. Positive association between concentration of phthalate metabolites in urine and microparticles in adolescents and young adults. Environment International 2016 Jul-Aug; 92-93: 157-164. https://doi.org/10.1016/j.envint.2016.04.006
  • Phthalates: Lin CY, Chen PC, Hsieh CJ, Chen CY, Hu A, Sung FC, Lee HL, Su TC. Positive association between urinary concentration of phthalate metabolites and oxidation of DNA and lipid in adolescents and young adults. Scientific Reports 2017 Mar; 7: 44318. https://doi.org/10.1038/srep44318
  • Phthalates: Chen SY, Hwang JS, Sung FC, Lin CY, Hsieh CJ, Chen PC, Su TC. Mono-2-ethylhexyl phthalate associated with insulin resistance and lower testosterone levels in a young population. Environmental Pollution 2017 Jun; 225: 112-117. https://doi.org/10.1016/j.envpol.2017.03.037
  • Phthalates: Chang JW, Liao KW, Huang CY, Huang HB, Chang WT, Jaakkola JJK, Hsu CC, Chen PC, Huang PC. Phthalate exposure increased the risk of early renal impairment in Taiwanese without type 2 diabetes mellitus. International Journal of Hygiene and Environmental Health 2019 Mar; 224: 113414; doi: 10.1016/j.ijheh.2019.10.009. https://doi.org/10.1016/j.ijheh.2019.10.009
  • ​Phthalates: Lee SH, Du ZY, Tseng WC, Lin WY, Chen MH, Lin CC, Liang HJ, Wen HJ, Guo YL, Chen PC, Lin CY. Identification of serum metabolic signatures of environmental-leveled phthalate in the Taiwanese child population using NMR-based metabolomics. Environmental Pollution 2023 Jan; 316(Pt 1): 120454. https://doi.org/10.1016/j.envpol.2022.120454
  • Phenolic compounds: Lin CC, Chien CJ, Tsai MS, Chen MH, Hsieh WS, Chen PC. Prenatal phenolic compounds exposure and neurobehavioral development at 2 and 7 years of age. Science of the Total Environment 2017 Dec; 605-606: 801-810. https://doi.org/10.1016/j.scitotenv.2017.06.160
  • Phenolic compounds: Lin CY, Shen FY, Lian GW, Chien KL, Sung FC, Chen PC, Su TC. Association between levels of serum bisphenol A, a potentially harmful chemical in plastic containers, and carotid artery intima-media thickness in adolescents and young adults. Atherosclerosis 2015 Aug; 241(2): 657-663. https://doi.org/10.1016/j.atherosclerosis.2015.06.038
  • Phenolic compounds: Lin CY, Hwang YT, Chen PC, Sung FC, Su TC. Association of serum levels of 4-tertiary-octylphenol with cardiovascular risk factors and carotid intima-media thickness in adolescents and young adults. Environmental Pollution 2019 Mar; 246: 107-113. https://doi.org/10.1016/j.envpol.2018.11.110
  • Parabens: Tung CJ, Lin CC, Chen MH, Chen PC. Association between parabens exposure and neurodevelopment in children. Environment International 2024 Jun; 188: 108671. https://doi.org/10.1016/j.envint.2024.108671
  • Pesticides: Liao HT, Hsieh CJ, Chiang SY, Lin MH, Chen PC, Wu KY. Simultaneous analysis of chlorpyrifos and cypermethrin in cord blood plasma by online solid-phase extraction coupled with liquid chromatography-heated electrospray ionization tandem mass spectrometry. Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 2011 Jul; 879(21): 1961-1966. https://doi.org/10.1016/j.jchromb.2011.05.028
  • Pesticides: Chiu KC, Sisca F, Ying JH, Tsai WJ, Hsieh WH, Chen PC, Liu CY. Prenatal chlorpyrifos exposure in association with PPARγ H3K4me3 and DNA methylation levels and child development. Environmental Pollution 2021 Apr; 274: 116511. https://doi.org/10.1016/j.envpol.2021.116511
  • ​Acrylamide: Lin CY, Lin YC, Kuo HK, Hwang JJ, Lin JL, Chen PC, Lin LY. Association among acrylamide, blood insulin, and insulin resistance in adults. Diabetes Care 2009 Dec; 32(12): 2206-2211. https://doi.org/10.2337/dc09-0309e
  • Acrylamide: Chu PL, Lin LY, Chen PC, Su TC, Lin CY. Negative association between acrylamide exposure and body composition in adults: NHANES, 2003-2004. Nutrition and Diabetes 2017 Mar; 7(3): e246. https://doi.org/10.1038/nutd.2016.48
  • Acrylamide: Lin CY, Lee HL, Chen YC, Lin LY, Wen LL, Lien GW, Chien KL, Sung FC, Chen PC, Su TC. Positive association between urinary levels of 8-hydroxydeoxyguanosine and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. Journal of Hazardous Materials 2013 Oct; 261: 372-377. https://doi.org/10.1016/j.jhazmat.2013.06.069
  • Acrylamide: Lin CY, Lin LY, Chen YC, Wen LL, Chien KL, Sung FC, Chen PC, Su TC. Association between measurements of thyroid function and the acrylamide metabolite N-acetyl-S-(propionamide)-cysteine in adolescents and young adults. Environmental Research 2015 Jan; 136: 246-252. https://doi.org/10.1016/j.envres.2014.08.043
  • Acrylamide: Chiu SY, Lin MH, Ho WC, Lin HT, Chen PC, Huang HY. Application of food description to the food classification system: evidence of risk assessment from Taiwan as acrylamide of grain products. Journal of Food and Drug Analysis 2018 Oct; 26(4): 1312-1319. https://doi.org/10.1016/j.jfda.2018.04.002
  • ​Polychlorinated biphenyls: Yang CY, Wang YJ, Chen PC, Tsai SJ, Guo YL. Exposure to a mixture of polychlorinated biphenyls and polychlorinated dibenzofurans resulted in a prolonged time to pregnancy in women. Environmental Health Perspectives 2008 May; 116(5): 599-604. https://doi.org/10.1289/ehp.10715
  • Polychlorinated biphenyls: Li MC, Tsai PC, Chen PC, Hsieh CJ, Guo YL, Rogan WJ. Mortality after exposure to polychlorinated biphenyls and dibenzofurans: 30 years after the “Yucheng Accident”. Environmental Research 2013 Jan; 120: 71-75. https://doi.org/10.1016/j.envres.2012.09.003
  • Polychlorinated biphenyls: Li MC, Wu HP, Yang CY, Chen PC, Lambert GH, Guo YL. Gestational exposure to polychlorinated biphenyls and dibenzofurans induced asymmetric hearing loss: Yucheng children study. Environmental Research 2014 Feb; 137: 65-71. https://doi.org/10.1016/j.envres.2014.12.002
  • Polychlorinated biphenyls: Li MC, Chen PC, Tsai PC, Furue M, Onozuka D, Hagihara A, Uchi H, Takesumi Y, Guo YL. Mortality after exposure to polychlorinated biphenyls and polychlorinated dibenzofurans: a meta-analysis of two highly exposed cohorts. International Journal of Cancer 2015 Sep; 137(6): 1427-1432. https://doi.org/10.1002/ijc.29504
  • Dioxins: Ho CC, Chan CC, Chio CP, Lai YC, Chang-Chien GP, Chow JC, Watson JG, Chen LWA, Chen PC, Wu CF. Source apportionment of mass concentration and inhalation risk with long-term ambient PCDD/Fs measurements in an urban area. Journal of Hazardous Materials 2016 Nov; 317: 180-187. https://doi.org/10.1016/j.jhazmat.2016.05.059

- Taiwan Human Biomonitoring and Epidemiology

  • Phthalates: Liao KW, Chang WH, Chou WC, Huang HB, Waits A, Chen PC, Huang PC. Human biomonitoring reference values and characteristics of phthalate exposure in the general population of Taiwan: Taiwan Environmental Survey for Toxicants 2013-2016. International Journal of Hygiene and Environmental Health 2021 Jun; 235: 113769.  https://doi.org/10.1016/j.ijheh.2021.113769
  • Beta-adrenergic agonists: Wang CJ, Liu HJ, Chou TC, Lin CC, Pan WH, Chen PC, Hsu JF. Simultaneous determination of eight beta-adrenergic agonists in human urine by an isotope dilution-online clean-up system coupled with liquid chromatography-tandem mass spectrometry. Chemosphere 2022 Aug; 301: 134778.  https://doi.org/10.1016/j.chemosphere.2022.134778
  • Heavy metals: Liao KW, Chen PC, Chou WC, Shiue I, Huang HI, Chang WT, Huang PC. Human biomonitoring reference values, exposure distribution, and characteristics of metals in the general population of Taiwan: Taiwan environmental survey for Toxicants (TESTs), 2013–2016. International Journal of Hygiene and Environmental Health 2023 Jul; 252: 114195.  https://doi.org/10.1016/j.ijheh.2023.114195

​- Air Pollution Epidemiology

  • Tang FC, Chen PC, Chan CC, Tsou Yau KI, Wang JD. Predictive pulmonary function of school children in an area of low air pollution in Taiwan. Journal of the Formosan Medical Association 1997 Jun; 96(6): 397-404. PubMed
  • Tang FC, Chan CC, Chen PC, Tsou Yau KI, Hwang JS, Wang JD. Absenteeism due to respiratory morbidity in elementary schools with low level air pollution. Chinese Journal of Public Health (Taipei) 1995 Apr; 14(2): 201-211.  https://doi.org/10.6288/CJPH1995-14-02-09
  • Chen PC, Lai YM, Wang JD, Yang CY, Hwang JS, Kuo HW, Hwang SL, Chan CC. Adverse effect of air pollution on respiratory health in primary school children in Taiwan. Environmental Health Perspectives 1998 Jun; 106(6): 331-335.  https://doi.org/10.1289/ehp.98106331
  • Chen PC, Lai YM, Chan CC, Hwang JS, Yang CY, Wang JD. Short-term effect of ozone on pulmonary function of primary schoolchildren. Environmental Health Perspectives 1999 Nov; 107(11): 921-925. https://doi.org/10.1289/ehp.99107921
  • Lin CC, Yang SK, Lin KC, Ho WC, Hsieh WS, Shu BC, Chen PC. Multilevel analysis of air pollution and early childhood neurobehavioral development. International Journal of Environmental Research and Public Health 2014 Jul; 11(7): 6827-6741. https://doi.org/10.3390/ijerph110706827
  • Tseng E, Ho WC, Lin MH, Cheng TJ, Chen PC, Lin HH. Chronic exposure to particulate matter and risk of cardiovascular mortality: cohort study from Taiwan. BMC Public Health 2015 Sep;15: 936. https://doi.org/10.1186/s12889-015-2272-6
  • Huang CY, Liu CL, Chen MH, Tsao PN, Chen CY, Chou HC, Chen PC. Maternal exposure to air pollution and the risk of small for gestational age in offspring: A population-based study in Taiwan. Pediatrics and Neonatology 2020 Apr; 61(2): 231-237.  https://doi.org/10.1016/j.pedneo.2019.11.008
  • Chen YT, Liu CL, Chen CJ, Chen MH, Chen CY, Tsao PN, Chou HC, Chen PC. Association between short-term exposure to air pollution and sudden infant death syndrome. Chemosphere 2021 May; 271: 129515.  https://doi.org/10.1016/j.chemosphere.2020.129515
  • Chen SF, Chien YH, Chen PC. The association between long-term ambient fine particulate exposure and the mortality among adult patients initiating dialysis: a retrospective nationwide cohort study in Taiwan. Environmental Pollution 2023 Jan; 316(Pt 2): 120606. https://doi.org/10.1016/j.envpol.2022.120606
  • Chen SF, Chien YH, Lai YC, Chen PC. Associations of long-term PM10 exposure with mortality in dialysis patients: a population based cohort study. Aerosol and Air Quality Research 2024 Jul; 24(7): 240028.  https://doi.org/10.4209/aaqr.240028
  • Chen BY, Chen CH, Chen PC, Wang GS, Guo YL. Air pollution, allergic co-morbidity, and emergency department visit for pediatric asthma in Taiwan. Aerosol and Air Quality Research 2013 Dec; 13(6): 1847-1852.  https://doi.org/10.4209/aaqr.2012.11.0299
  • Huang C, Wen H, Chen P, Chiang T, Lin S, Guo YL. Prenatal air pollutant exposure and occurrence of atopic dermatitis. British Journal of Dermatology 2015 Oct; 173(4): 981-988. https://doi.org/10.1111/bjd.14039
  • Shih P, Wu CD, Chiang TL, Chen PC, Su TC, Cheng TJ, Chen YH, Guo YL. The association between postpartum depression and air pollution during pregnancy and postpartum period: a national population study in Taiwan. Environmental Research Letters 2021 Aug; 16(8): 084021. https://doi.org/10.1088/1748-9326/ac1224
  • Chin WS, Pan SC, Huang CC, Chen YC, Hsu CY, Lin P, Chen PC, Guo YL. Proximity to petrochemical industrial parks and risk of chronic glomerulonephritis. Environmental Research 2022 May; 208; 112700.  https://doi.org/10.1016/j.envres.2022.112700
  • Huang CC, Pan SC, Chin WS, Chen YC, Wu CD, Hsu CY, Lin P, Chen PC, Guo YL. Living proximity to petrochemical industries and the risk of attention-deficit/hyperactivity disorder in children. Environmental Research 2022 Sep; 212(Part A): 113128. https://doi.org/10.1016/j.envres.2022.113128
  • Hsu CY, Wu PY, Chen YC, Chen PC, Guo YL, Lin YJ, Lin P. An integrated strategy by using long-term monitoring data to identify volatile organic compounds of high concern near petrochemical industrial parks. Science of the Total Environment 2022 May; 821: 153345. https://doi.org/10.1016/j.scitotenv.2022.153345
  • Hsu CY, Xie HX, Wong PY, Chen YC, Chen PC, Wu CD. A mixed spatial prediction model in estimating spatiotemporal variations in benzene concentrations in Taiwan. Chemosphere 2022 Aug; 301: 134758.  https://doi.org/10.1016/j.chemosphere.2022.134758
  • Babaan J, Hsu FT, Wong PY, Chen PC, Guo YL, Lung SCC, Chen YC, Wu CD. A Geo-AI-based ensemble mixed spatial prediction model with fine spatial-temporal resolution for estimating daytime/nighttime/daily average ozone concentrations variations in Taiwan. Journal of Hazardous Materials 2023 Mar; 446: 130749. https://doi.org/10.1016/j.jhazmat.2023.130749
  • Hsu CY, Lee RQ, Wong PY, Lung SCC, Chen YC, Chen PC, Adamkiewiczi G, Wu CD. Estimating morning and evening commute period O3 concentration in Taiwan using a fine spatial-temporal resolution ensemble mixed spatial model with Geo-AI technology. Journal of Environmental Management 2024 Feb; 351: 119725. https://doi.org/10.1016/j.jenvman.2023.119725
  • Asri AK, Lee HY, Chen YL, Wong PY, Hsu CY, Chen PC, Lung SCC, Chen YC, Wu CD. A machine learning-based ensemble model for estimating diurnal variations of nitrogen oxide concentrations in Taiwan. Science of the Total Environment 2024 Mar; 916: 170209. https://doi.org/10.1016/j.scitotenv.2024.170209
  • Babaan J, Wong PY, Chen PC, Chen HL, Lung SC, Chen YC, Wu CD. Geospatial artificial intelligence for estimating daytime and nighttime nitrogen dioxide concentration variations in Taiwan: A spatial prediction model. Journal of Environmental Management 2024 Jun; 360: 121198. https://doi.org/10.1016/j.jenvman.2024.121198
  • Lin YJ, Hsu CW, Lee CH, Zeng YT, Wong PY, Chen PC, Chen YC, Wu CD. The long-term trend analysis of PM2.5 variability from 1994 to 2020 using a hybrid spatial model: a case study of Taichung City, Taiwan. Journal of Photogrammetry and Remote Sensing 2024 Jun; 29(2): 65-75. https://doi.org/10.6574/JPRS.202406_29(2).0001
  • Chen MJ, Guo YL, Lin P, Chiang HC, Chen PC, Chen YC. Air quality health index (AQHI) based on multiple air pollutants and mortality risks in Taiwan: construction and validation. Environmental Research 2023 Aug; 231(Part 2): 116214.  https://doi.org/10.1016/j.envres.2023.116214
  • Chen CC, Wang YR, Liu JH, Chang HY, Guo YL, Chen PC. Burden of cardiovascular disease attributable to long-term exposure to ambient PM2.5 concentration and the cost-benefit analysis for the optimal control level. Science of the Total Environment 2023 Sep; 892: 164767. https://doi.org/10.1016/j.scitotenv.2023.164767
  • Chen CC, Wang YR, Liu JS, Chang HY, Chen PC. Associations between long-term ambient PM2.5 exposure and the incidence of cardiopulmonary diseases and diabetes, attributable years lived with disability, and policy implication. Ecotoxicology and Environmental Safety 2024 Sep; 282: 116688. https://doi.org/10.1016/j.ecoenv.2024.116688
  • Kono M, Su TY, Chang YY, Chou CC, Lee CT, Chen PC, Wu WT. Assessing the impact of specific PM2.5-bound metallic elements on asthma emergency department visits: a case-crossover study in Taiwan. Environmental Research 2024 Aug; 255: 119130. https://doi.org/10.1016/j.envres.2024.119130
  • Jang TY, Ho CC, Wu CD, Dai CY, Chen PC. Air pollution impede ALT normalization in chronic hepatitis B patients treated with nucleotide/nucleoside analogues. Medicine 2023 Oct; 102(43): e34276. https://doi.org/10.1097/MD.0000000000034276
  • Jang TY, Ho CC, Liang PC, Wu CD, Wei YJ, Tsai PC, Hsu PY, Hsieh MY, Lin YH, Hsieh MH, Wang CW, Yang JF, Yeh ML, Huang CF, Dai CY, Chuang WL, Huang JF, Cheng YY, Chen PC, Yu ML. Air pollution associate with advanced hepatic fibrosis among patients with chronic liver disease. Kaohsiung Journal of Medical Sciences 2024 Mar; 40(3): 304-314.  https://doi.org/10.1002/kjm2.12781
  • Jang TY, Ho CC, Wu CD, Dai CY, Chen PC. Air pollution as a potential a risk factor for hepatocellular carcinoma in Taiwanese patients after adjusting for chronic viral hepatitis. Journal of the Chinese Medical Association 2024 Mar; 87(3): 287-291. https://doi.org/10.1097/JCMA.0000000000001053
  • Jang TY, Ho CC, Wu CD, Dai CY, Chen PC. Air pollution as a potential a risk factor for pancreatic cancer and cholangiocarcinoma in Taiwanese patients. Advances in Digestive Medicine 2024; accepted.
  • Wu WT, Kono M, Lee CP, Chang YY, Yang YH, Lin CC, Liu TM, Li HC, Chen YM, Chen PC. Climate change projections for stroke incidence in Taiwan: impact of 2°C and 4°C global warming level. Journal of Epidemiology and Global Health 2024 Sep; 14(3): 1319-1331. https://doi.org/10.1007/s44197-024-00289-3

- Aristolochic Acid Related Diseases

  • Yang HY, Chen PC, Wang JD. Chinese herbs containing aristolochic acid associated with renal failure and urothelial carcinoma: a review from epidemiologic observations to causal inference. BioMed Research International 2014 Aug; 2014: 569325. https://doi.org/10.1155/2014/569325
  • Lai MN, Lai JN, Chen PC, Tseng WL, Chen YY, Hwang JS, Wang JD. Increased risks of chronic kidney disease associated with prescribed Chinese herbal products suspected to contain aristolochic acid. Nephrology (Carlton) 2009 Apr; 14(2): 227-234. https://doi.org/10.1111/j.1440-1797.2008.01061.x
  • Lai MN, Lai JN, Chen PC, Hsieh SC, Hu FC, Wang JD. Risks of kidney failure associated with consumption of herbal supplements containing Mu Tong or Fangchi: A population based case-control study. American Journal of Kidney Diseases 2010 Mar; 55(3): 507-518. https://doi.org/10.1053/j.ajkd.2009.10.055
  • Lai MN, Wang SM, Chen PC, Chen YY, Wang JD. Population-based case-control study of Chinese herbal products containing aristolochic acid and urinary tract cancer risk. Journal of the National Cancer Institute 2010 Feb; 102(3): 179-186. https://doi.org/10.1093/jnci/djp467
  • Wang SM, Lai MN, Wei A, Chen YY, Pu YS, Chen PC, Wang JD. Increased risk of urinary tract cancer in ESRD patients associated with usage of Chinese herbal products suspected of containing aristolochic acid. PLoS ONE 2014 Aug; 9(8): e105218. https://doi.org/10.1371/journal.pone.0105218
  • Chen CJ, Yang YH, Lin MH, Lee CP, Tsan YT, Lai MN, Yang HY, Ho WC, Chen PC. Herbal medicine containing aristolochic acid and the risk of hepatocellular carcinoma in patients with hepatitis B virus infection. International Journal of Cancer 2018 Oct; 143(7): 1578-1587. https://doi.org/10.1002/ijc.31544
  • Chen CJ, Yang YH, Lin MH, Lee CP, Tsan YT, Lai MN, Yang HY, Doyle P, Ho WC, Chen PC. Herbal medicine containing aristolochic acid and the risk of primary liver cancer in patients with hepatitis C virus infection. Cancer Epidemiology, Biomarkers and Prevention 2019 Nov; 28(11): 1876-1883. https://doi.org/10.1158/1055-9965.EPI-19-0023
  • Chen CJ, Chiu WC, Tseng YH, Lin CM, Yang HY, Yang YH, Chen PC. Aristolochic acid and the risk of cancers in patients with diabetes: Nationwide population-based cohort study. Phytomedicine 2022 May; 99: 154023. https://doi.org/10.1016/j.phymed.2022.154023
  • Yang HY, Wang JD, Lo TC, Chen PC. Increased mortality risk of kidney and other urinary organs cancers in Chinese herbalists. Journal of Epidemiology 2009 Feb; 19(1): 17-23. https://doi.org/10.2188/jea.JE20080035
  • Yang HY, Wang JD, Lo TC, Chen PC. Increased risks of upper tract urothelial carcinoma in male and female Chinese herbalists. Journal of the Formosan Medical Association 2011 Mar; 110(3): 161-168. https://doi.org/10.1016/S0929-6646(11)60026-0
  • Yang HY, Wang JD, Lo TC, Chen PC. Occupational kidney disease among Chinese herbalists exposed to herbs containing aristolochic acids. Occupational and Environmental Medicine 2011 Apr; 68(4): 286-290. https://doi.org/10.1136/oem.2010.058594
  • Yang HY, Wang JD, Lo TC, Chen PC. Occupational exposure to herbs containing aristolochic acids increases the risk of urothelial carcinoma in Chinese herbalists. Journal of Urology 2013 Jan; 189(1): 48-52. https://doi.org/10.1016/j.juro.2012.08.090
  • Lin HH, Chou SA, Yang HY, Hwang YH, Kuo CH, Kao TW, Lo TC, Chen PC. Association of blood lead and mercury with estimated GFR in herbalists after the ban of herbs containing aristolochic acids in Taiwan. Occupational and Environmental Medicine 2013 Aug; 70(8): 545-551. https://doi.org/10.1136/oemed-2012-101066
  • Hoang ML, Chen CH, Chen PC, Roberts NJ, Dickman KG, Yun BH, Turesky RJ, Pu YS, Vogelstein B, Papadopoulos N, Grollman AP, Kinzler KW, Rosenquist TA. Aristolochic acid in the etiology of renal cell carcinoma. Cancer Epidemiology, Biomarkers and Prevention 2016 Dec; 25(12): 1600-1608. https://doi.org/10.1158/1055-9965.EPI-16-0219

- Shift Work and Working Time

  • ​Chang PJ, Chu LC, Hsieh WS, Chuang YL, Lin SJ, Chen PC. Working hours and risk of gestational hypertension and pre-eclampsia. Occupational Medicine (London) 2010 Jan; 60(1): 66-71. https://doi.org/10.1093/occmed/kqp119
  • Lin YC, Hsiao TJ, Chen PC. Persistent rotating shift-work exposure accelerates development of metabolic syndrome among middle-aged female employees: A five-year follow-up. Chronobiology International: The Journal of Biological & Medical Rhythm Research 2009 May; 26(4): 740-755. https://doi.org/10.1080/07420520902929029
  • Lin YC, Hsiao TJ, Chen PC. Shift work aggravates metabolic syndrome development among the early-middle-aged males with elevated ALT. World Journal of Gastroenterology 2009 Dec; 15(45): 5654-5661. https://doi.org/10.3748/wjg.15.5654
  • Lin YC, Chen JD, Lo SH, Chen PC. Worksite screening programs for predicting the development of metabolic syndrome in middle-aged employees: a five-year follow-up study. BMC Public Health 2010 Dec; 10: 747. https://doi.org/10.1186/1471-2458-10-747
  • Lin YC, Chen MH, Hsieh CJ, Chen PC. Effect of rotating shift work on childbearing and birth weight: a study of women working in a semiconductor manufacturing factory. World Journal of Pediatrics 2011 May; 7(2): 129-135. https://doi.org/10.1007/s12519-011-0265-9
  • Lin YC, Chen PC. Persistent rotating shift work exposure is a tough second hit contributing to abnormal liver function among on-site workers having sonographic fatty liver. Asia-Pacific Journal of Public Health 2015 Mar; 27(2): NP1765-NP1774. https://doi.org/10.1177/1010539512469248
  • Lin YC, Chen YC, Hsieh HI, Chen PC. Risk for work-related fatigue among the employees on semiconductor manufacturing lines. Asia-Pacific Journal of Public Health 2015 Mar; 27(2): NP1805-NP1818. https://doi.org/10.1177/1010539513490788
  • Lin YC, Hsieh IC, Chen PC. Long-term day-and-night rotating shift work poses a barrier to the normalization of alanine transaminase. Chronobiology International: The Journal of Biological & Medical Rhythm Research 2014 May; 31(4): 487-495. https://doi.org/10.3109/07420528.2013.872120
  • Lin YC, Hsieh IC, Chen PC. Utilizing the metabolic syndrome component count in workers’ health surveillance: an example of day-time vs. day-night rotating shift workers. International Journal of Occupational Medicine and Environmental Health 2015 Aug; 28(4): 675-688. https://doi.org/10.13075/ijomeh.1896.00335
  • Lee HH, Lo SH, Chen BY, Lin YH, Chu D, Cheng TJ, Chen PC, Guo YL. Increased night duty loading of physicians caused elevated blood pressure and sympathetic tones in a dose-dependent manner. International Archives of Occupational and Environmental Health 2016 Apr; 89(3): 413-423. https://doi.org/10.1007/s00420-015-1080-8
  • Lee HH, Chen BY, Pan SC, Lo SH, Chen PC, Guo YL. Effects of night duty events on blood pressure and autonomic modulation in physicians. American Journal of Industrial Medicine 2018 Aug; 61(8): 675-680.  https://doi.org/10.1002/ajim.22859
  • Wei CF, Chen MH, Lin CC, Guo YL, Lin SJ, Laio HF, Hsieh WS, Chen PC. Association between maternal shift work and infant neurodevelopmental outcomes: results from the Taiwan Birth Cohort Study with propensity score matched analysis. International Journal of Epidemiology 2019 Oct; 48(5): 1545-1555. https://doi.org/10.1093/ije/dyz045
  • Wei CF, Chen MH, Lin CC, Tsai MS, Guo YL, Lin SJ, Chavarro JE, Hsieh WS, Chen PC. Pre-pregnancy shift work’s influence on postpartum weight retention: body mass index’s role. Chronobiology International 2024 Aug; 41(8): 1156-1164.  https://doi.org/10.1080/07420528.2024.2382909
  • Liao CW, Wei CF, Chen MH, Hsieh WS, Lin CC, Chen PC. Association between maternal shift work during pregnancy child overweight and metabolic outcomes in early childhood. Frontiers in Public Health 2022 Sep; 10: 1006332. https://doi.org/10.3389/fpubh.2022.1006332

- Occupational Health Research

  • Steelworkers: Chen PC, Doyle PE, Wang JD. Respirable dust exposure and respiratory health in male Taiwanese steelworkers. Industrial Health 2006 Jan; 44(1): 190-199. https://doi.org/10.2486/indhealth.44.190
  • Drivers: Tsai JH, Yang YH, Ho PS, Wu TN, Guo YL, Chen PC, Chuang HY. Incidence and risk of fatal vehicle crashes among professional drivers: a population-based study in Taiwan. Frontiers in Public Health 2022 Mar; 10: 849547. https://doi.org/10.3389/fpubh.2022.849547
  • Doctors: Shang TF, Chen PC, Wang JD. Mortality of doctors in Taiwan. Occupational Medicine (London) 2011 Jan; 61(1): 29-32. https://doi.org/10.1093/occmed/kqq159
  • Doctors: Shang TF, Chen PC, Wang JD. Disparities in mortality among doctors in Taiwan: A 17-year follow-up study of 37,545 doctors. BMJ Open 2012 Feb; 2(1): e000382. https://doi.org/10.1136/bmjopen-2011-000382
  • Dentists: Shang TF, Chen PC, Wang JD. Mortality among dentists in Taiwan, 1985-2009. Journal of the Formosan Medical Association 2012 Oct; 111(10): 567-571. https://doi.org/10.1016/j.jfma.2011.06.010
  • Medical interns: Lin YH, Chen HY, Tsai SL, Chang LR, Chen PC. A prospective study of the factors associated with life quality during medical internship. PLoS ONE 2019 Aug; 14(8): e0220608. https://doi.org/10.1371/journal.pone.0220608
  • Occupational disability: Chen PC, Ho JJ, Wang JD. Determinants of return to work among permanently disabled workers resulting from occupational injury. Journal of University of Occupational and Environmental Health 1997 Mar; 19(Suppl): 184-190.
  • Occupational disability: Lin SH, Lee HY, Chang YY, Jang Y, Chen PC, Wang JD. Increased mortality risk for workers with a compensated, permanent occupational disability of the upper or lower extremities: A 21-year follow-up study. American Journal of Epidemiology 2010 Apr; 171(8): 917-923. https://doi.org/10.1093/aje/kwq003
  • Bladder cancer: Chen JN, Chen PC, Hsieh FY, Chen HW, Liu CH, Cheng TJ, Chen CJ, Huang JH, Chen KT. Environmental and occupational risk factors in bladder cancer. Epidemiology Bulletin 1999 Mar; 15(3): 35-49. https://doi.org/10.6525/TEB.199903_15(3).0001
  • Asbestos: Yang HY, Wang JD, Chen PC, Lee JJ. Pleural plaque related to asbestos mining in Taiwan. Journal of the Formosan Medical Association 2010 Dec; 109(12): 928-933. https://doi.org/10.1016/s0929-6646(10)60142-8
  • Asbestos: Yang HY, Shie RH, Chen PC. Pulmonary fibrosis in workers exposed to non-asbestiform tremolite asbestos minerals. Epidemiology 2013 Jan; 24(1): 143-149. https://doi.org/10.1097/EDE.0b013e31826b822d
  • Asbestos: Yang HY, Shie RH, Chen PC. Carving non-asbestiform tremolite and the risk of lung cancer: A follow-up mortality study in a historical cohort processing nephrite. Occupational and Environmental Medicine 2013 Dec; 70(12): 852-857. https://doi.org/10.1136/oemed-2013-101404
  • Asbestos: Yang HY, Huang SH, Shie RH, Chen PC. Cancer mortality in a population exposed to nephrite processing. Occupational and Environmental Medicine 2016 Aug; 73(8): 528-536. https://doi.org/10.1136/oemed-2016-103586
  • Pneumoconiosis: Yang HY, Chen PC, Peng HY, Chang CJ. Diagnostic accuracy of breath tests for pneumoconiosis using an electronic nose. Journal of Breath Research 2018 Jan; 12(1): 016001. https://doi.org/10.1088/1752-7163/aa857d
  • Pneumoconiosis: Yang HY, Shie RH, Chang CJ, Chen PC. Development of breath test for pneumoconiosis: a case-control study. Respiratory Research 2017 Oct; 18: 178. https://doi.org/10.1186/s12931-017-0661-3
  • Talc: Chang CJ, Tu YK, Chen PC, Yang HY. Occupational exposure to talc increases the risk of lung cancer: a meta-analysis of occupational cohort studies. Canadian Respiratory Journal 2017 Aug; 2017: 1270608. https://doi.org/10.1155/2017/1270608
  • Talc: Chang CJ, Tu YK, Chen PC, Yang HY. Talc exposure and risk of stomach cancer: systematic review and meta-analysis of occupational cohort studies. Journal of the Formosan Medical Association 2020 Apr; 119(4): 781-792.  https://doi.org/10.1016/j.jfma.2018.07.015
  • Talc: Chang CJ, Yang YH, Chen PC, Peng HY, Lu YC, Song SR, Yang HY. Stomach cancer and exposure to talc powder without asbestos via Chinese herbal medicine: a population-based cohort study. International Journal of Environmental Research and Public Health 2019 Feb; 16(5): 717. https://doi.org/10.3390/ijerph16050717
  • Hydrofluoric acid: Shiau CY, Chen PC, Wang JD, Cheng TJ. Hydrofluoric acid burns caused by incompatible laboratory wastes. Taiwan Journal of Public Health 2001 Feb; 20(1): 69-73. https://doi.org/10.6288/TJPH2001-20-01-09
  • Epoxy adhesives: Yang HY, Shie RH, Chen PC. Hearing loss in workers exposed to epoxy adhesives and noise: a cross-sectional study. BMJ Open 2016 Feb; 6(2): e010533. https://doi.org/10.1136/bmjopen-2015-010533
  • Electronics: Huang WL, Guo YL, Chen PC, Wang J, Chu PC. Association between emotional symptoms and job demands in an Asian electronics factory. International Journal of Environmental Research and Public Health 2017 Sep; 14(9): 1085. https://doi.org/10.3390/ijerph14091085
  • Pregnant workers: Yeh S, Lee CN, Wu YH, Tu NC, Guo YL, Chen PC, Chen CH. Occupational hazard exposures and depressive symptoms of pregnant workers. Journal of Occupational and Environmental Medicine 2018 Mar; 60(3): e134-e138. https://doi.org/10.1097/JOM.0000000000001255
  • Pregnant workers: Shih P, Huang CC, Chiang TL, Chen PC, Guo YL. Attention deficit hyperactivity disorder among children related to maternal job stress during pregnancy in Taiwan: a prospective cohort study. International Archives of Occupational and Environmental Health 2022 Aug; 95(6): 1231-1241. https://doi.org/10.1007/s00420-021-01821-9
  • Carbon monoxide poisoning: Meng YH, Hsieh MS, Chi YC, How CK, Chen PC, Chang CM. Effect of carbon monoxide poisoning on epilepsy development: a nationwide population-based cohort study. Annals of Emergency Medicine 2023 Aug; 82(2): 145-151. https://doi.org/10.1016/j.annemergmed.2022.11.021
  • Ultrafine particle: Chang PK, Chuang HH, Hsiao TC, Chuang HC, Chen PC. Investigating the invisible threat: An exploration of air exchange rates and ultrafine particle dynamics in hospital operating rooms. Building and Environment 2023 Nov; 245: 110870. https://doi.org/10.1016/j.buildenv.2023.110870

- Occupational Health Service

  • Chen PC, Wang JD, Chang PJ, Peng TC. Enterprise-based occupational health management in the future of Taiwan – Recommendations based on a field trip of five American and Japanese companies. Journal of National Public Health Association (ROC) 1989 Aug; 9(4): 171-183. https://doi.org/10.6288/JNPHARC1989-09-04-01
  • Chen PC, Wang JD, Chang PJ. Quality assurance and control of medical examination in the workplace. Journal of National Public Health Association (ROC) 1990 Feb; 10(1): 1-10. https://doi.org/10.6288/JNPHARC1990-10-01-01
  • Chang PJ, Chen PC, Cheng TJ, Chen CJ. Occupational health services in medium- and large-sized factories and industrial zones of Taiwan. Journal of Occupational Safety and Health 2000 Dec; 8(4): 373-387. Abstract
  • Liu HC, Chen CY, Li C, Lin TH, Chen PH, Chen PC. The health impact of misinterpreted flexicurity: an example of the Amendments to the Labor Standard Act. Taiwan Journal of Public Health 2018 Feb; 37(1): 1-7.  https://doi.org/10.6288/TJPH201802_37(1).106139
  • Wei CF, Chen PH, Lin TH, Chen PC. International comparison of reporting and surveillance of novel occupational diseases. Journal of Labor, Occupational Safety and Health 2019 Sep; 27(3): 47-56. Abstract
  • Pan SC, Hsu MC, Chang HH, Wang JT, Lai YL, Chen PC, Chang SY, Sheng WH, Chen YC, Chen SC, Chang SC. Prospective health surveillance for COVID-19 among health care workers at a university medical center in Taiwan, January to June 2020. Journal of the Formosan Medical Association 2022 Mar; 121(3): 613-622.  https://doi.org/10.1016/j.jfma.2021.07.018
  • Tsou HH, Kuo SC, Lin YH, Hsiung CA, Chiou HY, Chen WJ, Wu SI, Sytwu HK, Chen PC, Wu MH, Hsu YT, Wu HY, Lee FJ, Shih SM, Liu DP, Chang SC. A comprehensive evaluation of COVID-19 policies and outcomes in 50 countries and territories. Scientific Reports 2022 May; 12: 8802. https://doi.org/10.1038/s41598-022-12853-7
  • Tsou HH, Lee FJ, Wu SI, Fan B, Wu HY, Lin YH, Hsu YT, Cheng C, Cheng YC, Jiang WM, Chiou HY, Chen WJ, Hsiung CA, Chen PC, Sytwu HK. Suppression of the alpha, delta, and omicron variants of SARS-Cov-2 in Taiwan. PLoS ONE 2024 Mar; 19(3): e0300303. https://doi.org/10.1371/journal.pone.0300303)
  • Shih P, Chu PC, Huang CC, Guo YL, Chen PC, Su TC. Hospital occupational health service network and reporting systems in Taiwan from 2008 to 2021. Journal of Occupational and Environmental Medicine 2023 Feb; 65(2): e43-e50. https://doi.org/10.1097/JOM.0000000000002751